During the course of a plague, Prince Prospero calls together his friends to come to his castle for fun and frolic until the danger of pestilence has passed. A masquerade is planned, and in typical "Poesque" fashion the great halls are described in imagery that foreshadows a horror to follow. The night of the ball comes, the guests arrive in their costumes and the festivities begin.

The gaiety is interrupted by the arrival of a guest, dressed in the garments of the grave besprinkled with the scarlet blood associated with the plague of "red death." The intruder stalks the halls until confronted by the host in (of course) the black hall. Without explanation, the host falls dead at the masquer's feet and the revelers, setting upon the intruder, find that the costume is "untenanted by any tangible form." Whereupon, the guests began to die in their tracks as they acknowledge the presence of the Red Death.